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SGOT (AST) in Liver Function Tests: Clinical Significance (CME INDIA) Serum glutamic-oxaloacetic transaminase (SGOT), now termed aminotransferase (AST), is a transaminase enzyme present in both the cytosol and mitochondria of hepatocytes and in high concentrations in cardiac muscle, skeletal muscle, kidney, brain, and red blood cells. Hence, AST is a sensitive but relatively non-specific marker of hepatocellular injury. AST elevation reflects cellular necrosis or membrane leakage but does not ex
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