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A functioning ribosome with only 19 amino acids
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A ribosome strings amino acids into a chain, but for proteins headed out of the cell or into a membrane, that chain is only a rough draft. A short signal sequence at the start of the protein tells the ribosome to dock onto the endoplasmic reticulum, and all those docked ribosomes are what make the rough ER look rough. As the chain grows, it threads straight into the ER, where it gets folded, has sugar groups attached and is checked for mistakes before being shipped to the Golgi. Proteins that fa
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